Transcriptional Aging in White Blood Cells
Integrated gene expression networks are essential for the normal functioning of healthy tissues. In this study, we investigate how age-related changes in the integrity of these networks, what we term "transcriptional wilting," contributes to inflammaging.
Integrated Omics of Bone
This research focuses on the identification of age-related metabolomic, proteomic, and transcriptomic changes that increase risk of bone fracture among the elderly. Identified pathways will be compared to data from skeletal muscle and liver to determine overlap within the musculoskeletal system and metabolically active tissues. A better understanding of age-related changes and the biology of bone aging in the context of the metabolic syndrome is essential to identifying novel targets for intervention to prevent fracture and preserve health and vitality among older individuals.